ϼü ν ִ ġ ũ ִ. ź(mitotane), Ʈνź(trilostane) ġ ϼü (hypophysectomy) װ̴.
ϼü ǽϴ ϼü ν(PDH) ȯ 10% Ȯ ִ ϰ θ ȭϱ CT, MRI ˻簡 ʿϸ , ν ռȣ ؾ ϴ ִ. Hanson JM, vant HM, Voorhout G 2005 ǥ (efficacy of transsphenoidalhypophysectomy in treatment of dogs with pituitary-dependent hyperadrenocorticism J Vet Intern Med 2005) 138 127 ġῡ ߰, 75% ʾ Ⱓ 28 ƴ.
12 Ǵ 4 ȿ , Ʈ, 索 , ߴ. ν ڱϴ ϴ ް ִ.
5.1kg 10 ũ ӵ ٴ ֵ ߴ. 2 (hematoma) ܵ ϴ ǽ ó(l/d) ϰ ־. Ѵ (weakness) (shivering) ־ٰ Ѵ. Ϸ翡 300~400ml Ÿ´.
װ˻翡 ȭ ó Ʒ 2 ġ Ҹ . ġ Ư̻ ʾҴ(ǥ 1).
ٴ(polyuria /polydipsia) ȣ ˻縦 ǽߴ.
ν ڱ ˻(ACTH-stimulation test) ǽ (ǥ 2) ν ־. ϼü θ Ǵϱ 뷮 Ÿ ڱ (LDDST, low dose dexamethasone stimulation test) μν ڱ ȣ (endogenous ACTH concentration)˻縦 ǽ (ǥ 3) ϼü ν ǽ ־.
Ȯ ٽ 뷮 Ÿ ڱؽ(HDDST) ǽ (ǥ 4) Ʒ Ǿ. ˻翡 1.013, pH 5 꼺, blood ++++ Ÿ.
缱 ˻翡 Ἦ Ұ Ǿ. ˻翡 Ἦ , νũ 6.7mm, ν ũ 7.3mm Ǿ.
ν ڱؽ(ACTH stimulation test), LDDST, HDDST, μ(endogenous) ACTH ˻ ϼü Ͼ ǴϿ ϼü ν ߴ.
ȯڴ ġ ϰ ź ġḦ Ͽ. Ա 뷮 ź Բ 25mg/kg bid óϰ Ŀ ϵ ߴ. Ա 뷮 3 ϰ Ŀ ߴٰ ǴϿ νڱ ǽߴ(ǥ 5).
Ǿ 뷮 2 ٽ ѹ ν ڱ ˻縦 ǽߴ. Ǿ Ǵϰ Ͽ ϴ Ͽ 4ְ ǽ ν ڱ ˻縦 ǽߴ.
4 ˻翡 ν е ʴ Ǵ Ʈνź ߴ. Ʈνź 1, 3 ° ƴ(ǥ 6).
ϼü ν ߴ.
Ʈνź 6mg/kg Բ sid Ͽ ٽ νڱؽ ǽߴ(ǥ 4).
T 5̻ Ƿ 50% Ͽ 9mg/kg sid ϰ 7 ˻Ͽ(ǥ 5).
ҵ ӻ ν ġμ ΰ ʱ ܰ ̷ , ȣ δ ġ ȣȴ. ź(mitotane) Ա Ѵ. ʱ Ա 5~14 ̸, 50mg/kg/day 뷮 Բ ؾ Ѵ.
Ա ACTH ڱؽ ġ Ʒ Ѵ. ȣڿ Ŀ̳ , ൿ̻, , ϰ Ͽ ̻ ϸ 24ð ȿ ACTH ڱؽ ǽϿ ԱⰡ Ǿ ǴѴ. Ǹ 1, 3 Ŀ ٽ ν ڱؽ ǽϿ Ѵ. Ŀ(baker) 2005 ǥ 60 ջ Ⱓ 30̾.
Ʈνź(trilostane) Ա 5kgϴ 30mg SID or EOD, 5~20kg 60mg SID, 20kg̻ 120mg SID ϸ ȴ. Ŀ 2005 ǥ 123 Ⱓ 662̶ Ѵ.